Drug to reduce children’s peanut allergies shows early promise

Peanut allergy could be beaten by building up tolerance, study finds

But that improvement came at a cost - almost all of the study participants who received the drug, a pharmaceutical-grade preparation of peanut flour, suffered adverse events of some type, and 1 in 10 withdrew from the trial because of gastrointestinal, skin or respiratory problems or systemic allergic reactions. Participants of the PALISADE trial were instructed to continue the standard of care for peanut allergy, which meant eliminating peanuts from their diets and carrying self-injectable epinephrine (an emergency medical treatment for accidental exposure). Twenty-five percent of children who had received AR101 experienced moderate symptoms during a food challenge at the end of the treatment, versus 59 percent of participants who had been given a placebo.

Dr. Allan Stillerman, a Twin Cities allergist with Allergy & Asthma Specialists and a member of the Clinical Research Institute, says he's optimistic about this new treatment for peanut allergies - especially among children.

"This is extremely good news as the number of children being diagnosed with peanut allergy in the United Kingdom has more than doubled over the past two decades".

"By significantly reducing the frequency and severity of allergic reactions to peanut, AR101 could provide reassurance and make a meaningful, beneficial impact on people's daily lives", Burks said. A person in an OFC is given a very small dose of the food by mouth under the supervision of a board-certified allergist to test for a severe reaction.

Doses were gradually increased every two weeks for a period of six months, before continuing on a "maintenance dose" of peanut for a further six months. "Before Emily took part we were uncomfortable being more than twenty minutes away from a hospital and she wasn't able to attend play dates or parties without me or my husband being there".

Wizards ‘giving impression’ Wall, Beal could be available in trade
They have a few big contracts on the books, headlined by Wall's $170 million extension that kicks in next season. For the right price, your favorite National Basketball Association franchise can have its own Wizard.

Smith breaks fibula, tibia in right leg
The Washington Redskins welcomed the Houston Texans to the capital yesterday, with a 6-3 record that saw them top of the NFC East. The 34-year-old did the damage while being sacked in the third quarter and was replaced by Colt McCoy under center.

Instagram ousting fake followers from accounts
The removal process will be complete once a user logs back onto Instagram , and changers the account password. Photo-sharing platform Instagram has announced a new initiative that will target fake likes and comments.

Aimmune Therapeutics (NASDAQ:AIMT) is up 6% premarket, albeit on only 800 shares, on the heels of the publication in the New England Journal of Medicine of results from the Phase 3 PALISADE study evaluating AR101 in patients with peanut allergy. Furthermore, two-thirds of the people were able to tolerate the equivalent of two peanuts per day after nine to 12 months of treatment, and half the patients tolerated the equivalent of four peanuts.

Ms Pratt said by the end of the year-long trial Emily was able to tolerate around seven peanuts.

"Until recently there has been nothing to offer peanut allergy suffers other than education around peanut avoidance and recognition and self-treatment of allergic reactions".

Emily has had a peanut allergy since she was one and her mum says the study is life-changing. They account for the majority of deaths related to food allergy.

Related news:

Hot News

isis-killer-beheading-video-story-top NASA to review workplace safety culture at SpaceX, Boeing
Nov 22, 2018 - 01:48
NASA revealed the nine astronauts that will take to space aboard the Boeing CST-100 Starliner and SpaceX Crew Dragon earlier this year.

isis-killer-beheading-video-story-top E. Coli Outbreak in Ontario, Quebec Linked to Romaine Lettuce
Nov 22, 2018 - 01:16
WGS performed on E. coli bacteria from ill people in this outbreak showed that the strains were closely related genetically. At this time, no common grower, supplier, distributor, or brand of romaine lettuce has been identified.

isis-killer-beheading-video-story-top Tony Gonzalez and Ed Reed highlight 2019 NFL Hall of Fame semifinalists
Nov 22, 2018 - 01:12
Johnson helped build the Dallas Cowboys dynasty in the 1990s and won two Super Bowl championships as the team's head coach. Already finalists for the hall are contributors Gil Brandt and Pat Bowlen, and senior committee nominee Johnny Robinson.

isis-killer-beheading-video-story-top Health officials urge people to avoid romaine lettuce amid E. coli outbreak
Nov 21, 2018 - 02:18
In last year's outbreak, 25 people across 15 states became sick after eating romaine lettuce with that bacterial strain. Additionally, you should make sure to wash and sanitize drawers or shelves in refrigerators where romaine was stored.

isis-killer-beheading-video-story-top IPad Pro 11 gets put through scratch, burn and bend testing
Nov 21, 2018 - 01:59
The iPad Pro 11 costs about as much as an iPhone XR , so in the grand scheme of Apple's devices it's quite reasonably priced. The most interesting, and hurtful, part though is the actual bend test.

isis-killer-beheading-video-story-top In threat to Pelosi, 16 Dems say they'll back new leadership
Nov 21, 2018 - 01:44
No challenger to Pelosi has come forward, though, and the letter didn't say what the group will do if no one emerges. Marcia Fudge (D-OH), who castigated Pelosi as a wealthy elitist in an interview with The Huffington Post last week.

isis-killer-beheading-video-story-top Cryptocurrency 'bloodbath' as Bitcoin falls 30% in a week
Nov 21, 2018 - 00:51
Bitcoin Cash is both a rival cryptocurrency to bitcoin and a fork or split-off of cryptocurrency that launched in August 2017 . XRP has been a market outlier over the past few days and has been relatively stable during these turbulent market conditions.

isis-killer-beheading-video-story-top Trump 'stands with' Saudi Arabia and defends crown prince over Khashoggi
Nov 21, 2018 - 00:45
He said the United States intends to remain a steadfast partner of Saudi Arabia to ensure the interests of the United States. US national security adviser John Bolton said earlier he didn't think the tape implicated the crown prince .

isis-killer-beheading-video-story-top Rooney picks out two "embarrassing" moments under Mourinho at Man Utd
Nov 20, 2018 - 01:47
"There are too many players who seem to be out of form or not stepping up". "Obviously, they are going to get back on top". West Ham United have been given new hope over the future of Declan Rice after encouraging comments.

isis-killer-beheading-video-story-top Colt McCoy throws for touchdown after Alex Smith injury
Nov 20, 2018 - 01:47
The Washington Redskins have signed free agent quarterback Mark Sanchez to back up Colt McCoy , according to multiple reports . After Sanchez's stint in NY , he bounced around, serving as the backup for Philadelphia, Dallas, Denver, and Chicago at times.

Ryan Reynolds Kidnaps Fred Savage in ‘Once Upon a Deadpool’ Trailer
Nov 20, 2018 - 01:45
Fred , 42, cut in saying: "I'm a grown man" but Deadpool continued 'and no one does childlike innocense like you, Fred , nobody. For every ticket sold, $1 will go to the charity Fudge Cancer (renamed for the PG-13 release ).

isis-killer-beheading-video-story-top The PS4 turns five-years-old, so here's its best-selling games
Nov 20, 2018 - 01:28
As of writing, you can already pick up this Black Friday's $100 off deal on the PlayStation 4 Slim 1TB Spider-Man Bundle. The console itself usually costs around $200, so this deal is getting you one of the best games of 2018 for free.

isis-killer-beheading-video-story-top Colorado man gets life for murders of pregnant wife, children
Nov 20, 2018 - 01:04
He also received a 48-year sentence for unlawful termination of a pregnancy and 12 years each for tampering with a human body. The girls' bodies were found submerged in an oil tank, on property owned by the company Watts worked for until his arrest.

isis-killer-beheading-video-story-top Blok drafts 'emergency law' to cover threat of no-deal Brexit
Nov 20, 2018 - 01:02
He also said another referendum - as demanded by some of his MPs - was "an option for the future but not an option for today". British media say there is a critical week ahead for the prime minister.

isis-killer-beheading-video-story-top White House to Revoke Acosta’s Press Pass Again at End of Month
Nov 20, 2018 - 00:33
Acosta had his White House press pass returned following a court injunction that will last for 14 days, expiring on 30 November. In light of the White House stance, CNN said it has asked Judge Timothy Kelly for another emergency hearing in the dispute.